Experimental drug shows early promise against inherited form of ALS, trial...
A clinical trial has found evidence that the experimental drug tofersen lowers levels of a disease-causing protein in people with an inherited form of amyotrophic lateral sclerosis, or ALS, caused by...
View ArticleScientists identify promising new ALS drug candidates
Scientists have taken a significant step forward in the search to find effective new drug candidates for the treatment of Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease.
View ArticleInvestigational drug stops toxic proteins tied to neurodegenerative diseases
An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein's...
View ArticleFaulty transportation of messenger RNA is the culprit in ALS
Researchers have discovered a function for the protein missing in many types of ALS and FTLD, two neurodegenerative diseases. In neurons, the protein TDP-43 bound to messenger RNA that codes for pieces...
View ArticleInvestigational ALS drug prolongs patient survival in clinical trial
An experimental medication that was recently shown to slow the progression of amyotrophic lateral sclerosis has now demonstrated the potential to also prolong patient survival. The findings come from a...
View ArticleNew biomarker candidate for amyotrophic lateral sclerosis
A research team has developed a diagnostic tool for the rare neurological disease amyotrophic lateral sclerosis (ALS). The study used the patented immuno-infrared sensor to analyze folding changes of...
View ArticleALS study reveals a unique population
The secrets long hidden in the DNA of patients with amyotrophic lateral sclerosis (ALS) living in Malta have been unlocked, according to a new study.
View ArticleALS neuron damage reversed with new compound
Scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a...
View ArticleStudy provides insights into architecture of abnormal protein deposits in...
Scientists have determined the structure of protein 'fibrils' linked to Lou Gehrig's disease and other neurodegenerative disorders -- findings that provide clues to how toxic proteins clump and spread...
View ArticleMotor neurons derived from patients point to new possible drug target for ALS
Researchers now report a high-throughput target and drug discovery platform using motor neurons made from ALS patients. Using the platform, they confirmed two known targets and identified an existing...
View ArticleA distinctive inflammatory signature found in a genetic form of ALS
Researchers find an increase in inflammatory molecules in serum and cerebrospinal fluid of C90RF72 patients, informing future anti-inflammatory therapies.
View ArticleDiscovery of the role of a key gene in the development of ALS
Amyotrophic lateral sclerosis, or ALS, attacks nerve cells known as motor neurons in the brain and spinal cord, gradually leading to paralysis. The loss of function of an important gene, C9orf72, may...
View ArticleResearch uncovers new insights on ALS and points to a potentially promising...
Investigators have found that an abnormal form of the tau protein is present in brain tissue from deceased patients who had amyotrophic lateral sclerosis (ALS). Cells that were grown in contact with...
View ArticleResearchers discover new insights about tau proteins in people living with ALS
Investigators found elevated levels of tau and a phosphorylated form of the tau protein in brain tissue from deceased people who had amyotrophic lateral sclerosis (ALS) and carried a mutation in the...
View ArticleRepurposed ALS drug shows promise in mouse model of rare childhood genetic...
Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in...
View ArticleALS therapy should target brain, not just spine
The brain is indeed a target for treating ALS (amyotrophic lateral sclerosis), scientists have discovered. This flips a long-standing belief the disease starts in the spinal motor neurons and any...
View ArticleDetailed images of molecule associated with ALS could open door to therapies
Scientists have determined the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases. The researchers say this discovery could...
View ArticleAstrocyte studies reveal harmful changes in amyotrophic lateral sclerosis
Scientists have revealed harmful changes in supporting cells, called astrocytes, in amyotrophic lateral sclerosis (ALS).
View ArticleNew meta-analysis explores potential environmental causes of ALS disease
In a new meta-analysis of available ALS literature, researchers explore environmental influences potentially linked ALS disease, using rigorous quantitative methods. The study also examines the...
View ArticleDiscovery of a new ALS and dementia disease mechanism raises treatment hopes
A pioneering new study has revealed, for the first time, why a common genetic variant worsens disease outcomes for people with the devastating adult-onset neurodegenerative diseases amyotrophic lateral...
View ArticleScientists discover a new molecular pathway shared by two neurodegenerative...
Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic...
View ArticlePotential window for treating ALS identified
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects as many as 30,000 people in the United States, with 5,000 new cases diagnosed each year. It weakens muscles over time,...
View ArticleNew ALS 'drug' is more effective than existing ones
New preclinical research on the experimental drug, NU-9, to treat ALS shows it is more effective than existing FDA-approved drugs for the disease. More importantly, NU-9 has an enhanced effect when...
View ArticleMuscle biopsy test for biomarker could lead to earlier diagnosis of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive disease of the nervous system. It affects nerve cells in the brain and spinal cord called motor neurons. Motor neurons control muscle movement and...
View ArticleALS may be linked to both the immune and central nervous systems
The immune system may play a fundamental role along with the central nervous system in amyotrophic lateral sclerosis (ALS), also known as 'Lou Gehrig's disease,' researchers report.
View ArticleFirst mouse model with mitochondrial tRNALeu mutation developed
Researchers have developed the first mouse model for a mitochondrial tRNALeu mutation, showing that the associated metabolic disorder results from faulty RNA processing.
View ArticlePromising MND drug helps slow disease progression and benefits patients...
Scientists believe a new genetically-targeted therapy to treat motor neurone disease (MND) could be a turning point for patient care, after the results of a Phase 3 clinical trial showed significant...
View ArticleInvestigational drug for genetic form of ALS improves disease's molecular signs
An international phase 3 clinical trial for a rare, inherited form of ALS showed that an investigational drug, known as tofersen, reduced molecular signs of disease, but at six months did not improve...
View ArticleNew analysis of cellular 'vehicles' drives a deeper understanding of ALS,...
Scientists have taken a key step toward better understanding neurodegenerative diseases by using a suite of biophysical techniques to learn more about a motor protein whose malfunction is associated...
View ArticleReading out RNA structures in real time
A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.
View ArticleRNA modification 'pivotal' for protein linked to neurodegeneration in ALS
Scientists know that TDP-43, which helps regulate processing of RNA, may be responsible for the death of nerve cells in ALS and frontotemporal dementia. And a study suggests that a common modification...
View ArticleResearchers discover therapeutic target to aid in glaucoma treatment
Researchers have identified a new therapeutic target that could lead to more effective treatment of glaucoma.
View ArticleDNA treatment could delay paralysis that strikes nearly all patients with ALS
Researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.
View ArticleParkinson's disease drug ropinirole safely slowed the progression of ALS for...
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles. There is no cure, and current...
View ArticleResearch reveals the scale of disorder underpinning Motor Neurone Disease
Researchers have shown that hundreds of proteins and mRNA molecules are found in the wrong place in nerve cells affected by Motor Neuron Disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS).
View ArticleNew insights into the protein-mediated motor neuron loss in amyotrophic...
Amyotrophic lateral sclerosis (ALS) is a widespread neurodegenerative disease caused by the loss of neurons that control movement. Although abnormal accumulation of proteins called TDP-43 accompanies...
View ArticleGuidelines follow advances in ALS gene discovery, ongoing gene therapy trials
Researchers have developed an evidence-based consensus guidelines for genetic testing and counseling for patients with amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that affects the...
View ArticleA promising drug candidate for ALS -- prolongs lifespan and eases symptoms in...
A research group has found a promising drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). Cerebral dopamine neurotrophic factor CDNF prolongs the lifespan of and alleviates...
View ArticleNew therapeutic strategy to reduce neuronal death in amyotrophic lateral...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects neurons in the brain and spinal cord causing loss of muscle control. Scientists have now suggested a potential...
View ArticleThis is how protein aggregates can trigger neurodegenerative diseases
Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death. Although the causal link between protein aggregates and...
View ArticleA molecular anchor
Scientists identify ALS-linked protein VAP as a key stabilizer of mitochondria near dendritic spines to support memory formation. This finding opens new directions for research into cognitive and motor...
View ArticleALS: Blocking inflammation to reduce symptoms
In people with amyotrophic lateral sclerosis (ALS), changes in neurons appear to activate immune cells. Lowering the inflammation could reduce the symptoms of the disease, according to a new study.
View ArticlePharmacological inhibitor protects nerve cells in ALS disease
A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease...
View ArticleCracking the code of neurodegeneration: New model identifies potential...
Scientists have developed an innovative neural cell culture model, shedding light on the intricate mechanisms underlying neurodegeneration. Their research pinpointed a misbehaving protein as a...
View ArticleRecreational activities such as golfing, gardening may be associated with...
Participation in recreational activities -- including golfing, gardening or yard work, woodworking and hunting -- may be associated with an increase in a person's risk for developing ALS. Researchers...
View ArticleIntegrity of blood-brain barrier depends on protein that is altered in some...
Defects in the blood vessel network of the central nervous system have been linked to early symptoms of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS)....
View ArticleNew immune cell therapy benefits laboratory models of ALS and has some...
The study provides the basis for a phase I clinical trial in additional participants.
View ArticleImaging technique uncovers protein abnormality in motor neurone disease
Researchers have used a new technique to identify pathological abnormalities associated with motor neurone disease.
View ArticleNew brain-computer interface allows man with ALS to 'speak' again
A new brain-computer interface translates brain signals into speech with up to 97 percent accuracy. Researchers implanted sensors in the brain of a man with severely impaired speech due to amyotrophic...
View ArticleTwo proteins identified as potential targets to improve ALS symptoms
Scientists have found that the protein histone H1.2 and the enzyme PARP1 could be potential therapeutic targets to decrease neurodegeneration in amyotrophic lateral sclerosis (ALS).
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